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POLYPEPTIDES DE RELAXINE MODIFIÉS ET LEURS UTILISATIONS
专利权人:
INC.;AMBRX
发明人:
KRAYNOV, VADIM,KNUDSEN, NICK,HEWET, AMHA,DE DIOS, KRISTINE,PINKSTAFF, JASON,SULLIVAN, LORRAINE
申请号:
EP11818758
公开号:
EP2605789A4
申请日:
2011.08.17
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Modified relaxin polypeptides and uses thereof are provided. In particular, modified relaxin polypeptide variants having substitutions with a non-naturally encoded amino acid in the A or B chain, especially residues 1, 5, 13, 18 and B chain residue 7. The non-natural amino acid is preferably a phenylalanine analog, especially para-acetyl-phenylalanine (pAcF or pAF). The relaxin variants are linked to compounds to improve their pharmacological properties, especially PEG having an average MW of between about 5 kDa and about 40 kDa , which is linked to the non-naturally encoded amino acid.
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