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ADMINISTRATION SOUS-CUTANEE D'ADENOVIRUS A DOUBLE CIBLAGE
专利权人:
NANT HOLDINGS IP; LLC;NANTCELL, INC.;NANT HOLDINGS IP, LLC
发明人:
SOON-SHIONG, PATRICK,NIAZI, KAYVAN,RABIZADEH, SHAHROOZ
申请号:
CA3014056
公开号:
CA3014056A1
申请日:
2017.02.12
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Immunotherapeutic methods and compositions are contemplated in which neoepitopes and/or tumor associated antigens are delivered to dendritic cells via an adenoviral expression system that targets MHC-I and/or MHC-II presentation systems and that further provides one or more recombinant peptides to stimulate T cell activation and interfere with checkpoint inhibition. Treatment is further supported by transfusion of NK cells, which may be modified to have a high affinity CD 16 receptor and/or a chimeric antigen receptor that binds to one or more neoepitopes and/or tumor associated antigens.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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