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Chemical modifications of monomers and oligonucleotides with cycloaddition
专利权人:
Muthiah Manoharan
发明人:
Muthiah Manoharan,Kallanthottathil G. Rajeev,Takeshi Yamada,David Butler,Narayanannair K. Jayaprakash,Muthusamy Jayaraman,Shigeo Matsuda,Rajendra K. Pandey,Chang Geng Peng
申请号:
US13120389
公开号:
US08962580B2
申请日:
2009.09.23
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention features compounds of formula I or II:In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
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