CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION

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专利权人:

Alnylam Pharmaceuticals; Inc.

发明人:

MANOHARAN, Muthiah,RAJEEV, Kallanthottathil G.,YAMADA, Takeshi,BUTLER, David,JAYAPRAKASH, K. Narayanannair,JAYRAMAN, Muthusamy,MATSUDA, Shigeo,PANDEY, Rajendra K.,PENG, Chang Geng

申请号：

AU2016202354

公开号：

AU2016202354B2

申请日:

2016.04.14

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

#$%^&*AU2016202354B220171116.pdf#####ABSTRACT The invention features compounds of formula I or II: A JI R5 B __ 5 B carrier )-L1O Q-L 11- LIGAND R4R R3 R2 J2 Formula (I) or B (II). In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. 7633082_1 '

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http://www.ckcest.cn/home/