POPOV, ALEXEY,ENLOW, ELIZABETH M.,BOURASSA, JAMES,GARDNER, COLIN R.,CHEN, HONGMING,ENSIGN, LAURA M.,LAI, SAMUEL K.,YU, TAO,HANES, JUSTIN,YANG, MING
申请号：
CA2871778
公开号：
CA2871778A1
申请日:
2013.05.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Compositions with improved particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions may include modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications.
