Conor Hayes,Arsen Volkov,Andrew Gerry,Ellen Border,Edward Carter
申请号：
US15480103
公开号：
US20170218043A1
申请日:
2017.04.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide GLYDGMEHL (SEQ ID NO: 1) derived from the MAGE-A10 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.
