JIN, BYUNG SUKKR,진병석,LIM, YOON MIKR,임윤미,PARK, SE YEONKR,박세연,JIN, BYUNG SUK,LIM, YOON MI,PARK, SE YEON
申请号：
KR1020150142194
公开号：
KR1020170043132A
申请日:
2015.10.12
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a method for producing a nano-flexible vehicle containing active components collected therein. More specifically, the method comprises the steps of: 1) producing a sol solution by adding a solvent in a mixture mixed with active components, phosphatide, and surfactants and by dissolving the same in a high temperature constant temperature tank； 2) producing lyotropic liquid gel by adding and magnetically agitating distilled water in the sol solution； 3) dispersing the gel in water in vehicle particles by continuously magnetically agitating the gel and slowly adding distilled water while applying shearing force； 4) treating ultrasonic waves on a suspension in which vehicle particles are dispersed； and 5) magnetically agitating the suspension treated by ultrasonic waves, and cooling the same at room temperature. When the method of the present invention is used, vehicles having several tens of nano-meters and having flexible membranes can be produced. Thus, the percutaneous absorption of active components collected in vehicles can be promoted. Moreover, by means of a simple process without a solvent evaporating step or a high pressure step, a vehicle can be produced, and hydrophilic active component collecting efficiency can be remarkably improved. A cosmetic formulation containing a nano-flexible vehicle produced by using the method shows thixotropy properties, thereby being able to be used in producing a cosmetic composition having a very excellent using sense.COPYRIGHT KIPO 2017본 발명은 활성성분을 포집한 나노 플렉시블 베시클의 제조 방법에 관한 것으로, 보다 구체적으로 1) 활성성분, 인지질 및 계면활성제를 혼합한 혼합물에 용매를 첨가하고 고온의 항온조에서 용해시켜 졸(sol) 용액을 제조하는 단계； 2) 졸 용액에 증류수를 첨가하고 자석 교반하여 유방성(lyotropic) 액정의 겔(gel)을 형성하는 단계； 3) 겔에 자석 교반을 계속함과 동시에 전단력을 가하면서 증류수를 서서히 첨가하여 겔을 베시클 입자로 물 속에 분산시키는 단계； 4) 베시클 입자가 분산된 현탁액에 초음파를 처리하는 단계； 및 5) 초음파를 처리한 현탁액을 자석 교반하면서 상온으로 냉각시키는 단계를 포함하는 활성성분을 포집한 나노 플렉시블 베시클의 제조 방법에 관한 것이다. 본 발명의 나노 플렉시블 베시클 제조 방법을 이용하면 유연한 막을 가지는 수십 나노 미터 크기의 베시클 제조가 가능하므로, 베시클에 포집된 활성성분의
