7- [3,5-dihydroxy-5-phenyl-pent-1-enyl) -cyclopentyl] -n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods of preparation and methods of use of the same
7- [3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl) -cyclopentyl] -n-ethyl-hept-5-enamide (bimatoprost) in crystalline form ii, methods for preparation and methods of use thereof. The present invention provides a novel crystalline form of bimatoprost, designated as crystalline form ii. This new crystalline form is the most stable form of bimatoprost. furthermore, bimatoprost crystalline form ii has been found to be readily prepared from the crystalline form.7-[3,5-di-hidroxi-2-(3-hidroxi-5-fenil-pent-1-enil)-ciclopentil]-n-etil-hept-5-enamida (bimatoprost) na forma cristalina ii, métodos para preparação e métodos de utilização da mesma. a presente invenção fornece uma nova forma cristalina de bimatoprost, designado como forma cristalina ii. esta nova forma cristalina é a forma mais estável de bimatoprost. além disso, verificou-se que a forma cristalina ii de bimatoprost é prontamente preparada a partir da forma cristalina.
