A conjugate of a tubulysin analog with branched linkers

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专利权人:

Hangzhou DAC Biotech Co. Ltd

发明人:

ZHAO, Robert Yongxin,YANG, Qingliang,HUANG, Yuanyuan,ZHAO, Linyao,GAI, Shun,YE, Hangbo,LEI, Jun,XU, Yifang,CAO, Mingjun,GUO, Huihui,JIA, Junxiang,TONG, Qianqian,LI, Wenjun,ZHOU, Xiaomai,XIE, Hongsheng

申请号：

AU2017445144

公开号：

AU2017445144A1

申请日:

2017.12.31

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/