Robert Yongxin ZHAO,Qingliang YANG,Yuanyuan HUANG,Linyao ZHAO,Shun GAI,Hangbo YE,Jun LEI,Yifang XU,Mingjun CAO,Huihui GUO,Junxiang JIA,Qianqian TONG,Wenjun LI,Xiaomai ZHOU,Hongsheng XIE,Lu BAI,Xiang C
申请号：
US16759175
公开号：
US20200276261A1
申请日:
2017.12.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
