ПАН Кларк (US),ЧЖОУ Цюнь (US),СТЕФАНО Джеймс (US),ДХАЛ Прадип (US),ЧЭНЬ Бо (US),ДЖАНОЛИО Диего (US),МИЛЛЕР Роберт (US),ЦЮ Хуавэй (US)
申请号：
RU2015142992
公开号：
RU2015142992A
申请日:
2014.03.10
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
