PAN CLARK,QIU HUAWEI,DHAL PRADEEP,CHEN BO,GIANOLIO DIEGO
申请号：
IN2498/KOLNP/2015
公开号：
IN2015KN02498A
申请日:
2015.07.30
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position (114), according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
