METHODE DE PRODUCTION DE POLYMORPHES CRISTALLINS D'ACIDE 2-(3-CYANO-4-(2-METHYLPROPYL)OXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLIQUE

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专利权人:

TEIJIN PHARMA LIMITED;KITAMURA, MITSUTAKA

发明人:

KITAMURA, MITSUTAKA

申请号：

CA2656264

公开号：

CA2656264C

申请日:

2007.06.22

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

A method for producing crystal A of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid by dissolving 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in methanol or a mixed solvent of methanoland water(the volume ratio of methanol to water is 90/10 or more), then adding wateruntil theratio of methanol to water becomes 7/3, and further adding a specific amountof a seedcrystal at a specific timing during the addition of water.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/