A non-aqueous topical composition comprising moxidectin, 1-50% of at least one C1-C6 alcohol, 1-20% of at least one thickener and a pharmaceutically acceptable oil. The composition may comprise 0.01-5% moxidectin. The alcohol may be isopropyl alcohol. The thickener may be polybutene, preferably with a molecular weight from 810 to 1800. The oil may be medium-chain triglycerides, particularly caprylic/capric triglycerides. The composition may also comprise a penetration enhancer such as PPG-2 myristyl ether propionate and at least one antioxidant such as tert-butyl hydroquinone, butylated hydroxyanisole or citric acid. The composition is for use as a medicament and/or in the treatment or prevention of endoparasites and/or ectoparasites in animals, particularly cats, dogs, sheep, cows or horses. The composition is produced by mixing the components in a nitrogen-rich oxygen-free atmosphere.
