4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS

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专利权人:

DOMPÉ FARMACEUTICI S.P.A.

发明人:

ARAMINI Andrea,BIANCHINI Gianluca,LILLINI Samuele

申请号：

US201616061850

公开号：

US2018319785(A1)

申请日:

2016.12.16

申请国别(地区):

美国

年份:

2018

代理人:

摘要：

The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I):;;Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold-induced and/or exacerbated-respiratory disorders, urological disorders, corneal disorders associated to disturbances in the production of the tears and/or altered blinking such as epiphora and dry eye disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/