INSTITUTE OF NUCLEAR ENERGY RESEARCH; ATOMIC ENERGY COUNCIL
发明人:
LIU, SHOW WEN,刘秀雯,劉秀雯,LIN, CHENG HSIEN,林正宪,林正憲,LIN, TSYH LANG,林次郎,林次郎,HSU, CHENG FANG,徐成芳,徐成芳,CHANG, YU,张瑜,張瑜
申请号：
TW099122971
公开号：
TWI410398B
申请日:
2010.07.13
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention provides a bifunctional compound with amino groups and N2S2ligands comprising two amides and two thiols to form coordination compounds. The bifunctional compound further comprises an amino group capable of binding with bioactive sub-stances with carboxylic acids or halide compounds. A method for preparing the bifunctional compound is also disclosed, wherein 6-aminohexanol and (N-[2-ethylthiol]3-aza-3-[2-ethylthiol] propi-onamide) are initial reactants, and thiol groups of (N-[2-ethylthiol]3-aza-3-[2-ethylthiol] propionamide) are further pro-tected.本發明提供一種含氨基及二氮二硫(N2S2)配位子之雙官能基化合物包含二醯胺與二硫醇,可形成電中性的錯合物,其更包含一個氨基,使其能與含羧酸之生物活性物質或鹵素之化合物產生化學鍵結而成為雙官能基化合物。本發明亦提供一種前述雙官能基化合物之製備方法,係以6-氨基己醇及N-[2-(乙基硫醇)]-3-氮雜-3-[2-(乙基硫醇)]正丙醯胺為起始反應物,而進一步將N-[2-(乙基硫醇)]-3-氮雜-3-[2-(乙基硫醇)]正丙醯胺之硫醇予以保護者。
