JORGE ANTONIO HERNANDEZ MIRAMONTES,JORGE ALBERTO HERNANDEZ VILLANUEVA
申请号：
DO2017000161
公开号：
DOP2017000161A
申请日:
2017.07.06
申请国别(地区):
DO
年份:
2017
代理人:
摘要：
Currently, the treatment for Patients with end-stage Renal Disease (Stage V) consists of renal replacement therapy (hemodialysisPeritoneal dialysis or Kidney Transplant； extraordinarily costly which leads to a poor quality of Life.The Invention is a mixture of carboxylic acids: Citric Acid, SUCCINIC ACID, fumaric acid and Malic acid, and all their possible combinations.The product is preferably used orally or intravenously in the treatment of patients with chronic renal failureHyperammonemia or human conditions that cause negative nitrogen balance.This product is beneficial for lowering Serum values of Serum urea and Ammonium, while the oxaloacetate by transamination formed via succinate, fumarate and Malate.Promotes the biosynthesis of non Essential Amino Acids； The Alpha Keto glutarate formed by transamination Pathway generates Citrate, glutamic acid and glutamine as the amino acids related to it.This treatment prevents, Preserving and even Improving renal function. In other patients, delay the deterioration of renal function and the urgent need for renal replacement therapy.In others, it is used as add-on therapy to renal replacement therapy to improve the patient's quality of Life and improve the laboratory parameters.Actualmente el tratamiento para pacientes con enfermedad renal terminal (estadio V) consiste en terapia renal sustitutiva (hemodiálisis, diálisis peritoneal o transplante renal)； extraordinariamente costosa que conlleva una pobre calidad de vida. Nuestro invento es una mezcla de ácidos carboxílicos: ácido cítrico, ácido succínico, ácido fumárico y ácido málico, y cualesquiera de sus combinaciones posibles. Dicho producto se utiliza preferentemente vía oral o también vía intravenosa, en el tratamiento de pacientes con insuficiencia renal crónica, hiperamonemia o condiciones humanas que cursen con balance nitrogenado negativo. Este producto es benéfico para disminuir los valores séricos de urea y de amonio sérico, a la vez que por transaminación del
