[Problem] To provide a drug cassette having a compact configuration and allowing drugs to be fed out one at a time using a first rotating body and a second rotating body, and also to provide a drug packaging device. [Solution] The following are arranged within a cassette main body: a cylindrical body (50) that accommodates drugs a first rotating body (51) that is disposed on the bottom surface side of the cylindrical body (50), and is rotatable around a first rotating shaft (17) and a second rotating body (52) that is disposed on the outer periphery of the opening in the cylindrical body (50), and is rotatable around a second rotating shaft (22). At least drive means (30, 31) that rotate and drive the first rotating body (51) and the second rotating body (52) are disposed in the remaining space in the cassette main body (49).