THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
发明人:
TWETEN, RODNEY K.
申请号：
CA2968398
公开号：
CA2968398A1
申请日:
2015.11.20
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced hemolytic activity and reduced pore-forming activity in comparison to their wild type protein. The present disclosure also provides, in various embodiments, nucleic acids which encode such mutants, and methods of the use of such mutants.
