The Board of Regents of the University of Oklahoma
发明人:
Rodney K. Tweten
申请号：
US15527919
公开号：
US10562941B2
申请日:
2015.11.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced hemolytic activity and reduced pore-forming activity in comparison to their wild type protein. The present disclosure also provides, in various embodiments, nucleic acids which encode such mutants, and methods of the use of such mutants.
