An apparatus and method for adapting a diagnostic model for Computer-Aided Diagnosis (CAD). The CAD apparatus includes an image acquirer configured to acquire an image of an object, a diagnosis model store configured to store at least one diagnostic model, an adaptive information provider configured to provide adaptive information regarding the image, a diagnostic model adapter configured to select a diagnostic model from the diagnostic model store and to generate an adapted diagnostic model based on the selected diagnostic model and the adaptive information, and a diagnoser configured to perform CAD on the image using the adapted diagnostic model.
