The present invention relates to the use of such an anti-CXCR4 antibody or binding fragment in the treatment of a disease wherein the monospecific antibody or binding fragment thereof to CXCR4, a mechanism of its development is related to the activation of CXCR4, as well as such an anti-CXCR4 antibody. It relates to a pharmaceutical composition comprising the antibody or the binding fragment.本発明は、CXCR4に対する単一特異的抗体又はその結合断片、その発生機序がCXCR4の活性化に関する疾患の治療におけるこのような抗CXCR4抗体又は結合断片の使用の他に、このような抗CXCR4抗体又は結合断片を含む医薬組成物に関する。