Clark Michael P.,Bandarage Upul K.,Deng Hongbo,Duffy John P.,Ledeboer Mark W.,Ledford Brian,Perola Emanuele,Charifson Paul S.,Davies Ioana,Bethiel Randy S.,Boyd Michael J.,Farmer Luc J.,Gao Huai,Gu We
申请号：
NZ71678312
公开号：
NZ716783A
申请日:
2012.08.01
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed are 3-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid and 3-((6-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl)amino)-4,4-dimethylpentanoic acid derivatives and analogues as represented by Formula (IV): or a pharmaceutically acceptable salt thereof, wherein: X1 is fluoro, chloro, trifluoromethyl, cyano, or methyl X2 is hydrogen, fluoro, or chloro Z1 is N or CH Z2 is N or CH, CF, or CCN R1, R2, and R3 are each independently methyl, fluoromethyl, trifluoromethyl, ethyl, 2-fluoroethyl, or 2,2,2,-trifluoroethyl R4 and R5 are hydrogen Q is –C(O)OR and R is hydrogen or alkyl provided that the compound of Formula (IV) is not (R)-3-((5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid. Also disclosed is a pharmaceutical composition which comprises a compound of Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, adjuvant or vehicle for treating or preventing influenza virus infection in a patient.
