Vasculature closure device delivery systems and methods are provided. In one or more embodiments, a vasculature closure device delivery system for intraluminally positioning a vasculature closure device against a puncture site existing in a wall of a vessel includes a loading tube configured to receive the vasculature closure device therein, a push rod configured to extend through the loading tube and to push the vasculature closure device out of the loading tube and into a lumen of the vessel, and an automatic deployment mechanism configured to detect when the vasculature closure device is positioned at the puncture site and to automatically deploy the vasculature closure device thereabout.
