TRIVEDI, Naimisha,BAKER-GLENN, Charles,VAN DE POEL, Herve,ARMANI, Elisabetta,BLACKABY, Wesley,CAPALDI, Carmelida,AMARI, Gabriele,LINNEY, Ian
申请号：
PE0025202016
公开号：
PE15572016A1
申请日:
2015.06.03
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Relates to compounds of formula I, where R1 is Hydrogen, halogen, c1-c4 alkyl R2 is Hydrogen, halogen, c1-c4 alkyl, among others M and N are 1 to 3 R3 and R4 are independently H (C3 - C7) cicloalquilcarbonilo R5, among others NO2 is CN, CF3, or halogeno K is 0, 1, 2 or 3 X is 0 OR 1 R6 is c1-c4 alkyl, alkoxy C1 - C4Among others R7 is Hydrogen or c1-c4 alkyl, optionally substituted l is a Union or \u2013ch2 L1 is a Union or - (CH2) P where p is 1 to 4 L2 is a Union - (CH2) Q, where q is 1 or 2 among others W1 is arylene or, heteroarileno heterocicloalquileno W2 is aryl or heteroaryl Group it is a Containing nitrogen such as - S - (CH2) nr8r9 where: s is 1 to 4R8 and R9 are Hydrogen or c1-c4 alkyl or a Heterocyclic Ring system is saturated or mono, Bi tricicliclos optionally substituted.Preferred compounds are: formate Salt of 5 - [[[1 - methyl - 2 - oxo - 1 - phenyl - 2 - [(3R) - 3 - quinuclidin - il] oxy] methyl] - ethyl] amino carboxylate tiofen - 2 - [(1S) - 2 - (3,5 - Dichloro - 1 1 - Oxide - pyridin - IO - 4-yl) - 1 - (3,4-dimethoxyphenyl) ethyl] - 4 - [[[1 - methyl - 2 - oxo - 1 - phenyl - 2 - [(3R) - 3 - quinuclidin Oxy - il] ethyl] amino] methyl] benzoate [(1S) - 2 - (3,5 - Dichloro - 1 - Oxide - pyridin - 1 Io - 4-yl) - 1 - (3,4-dimethoxyphenyl) ethyl], among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the Enzyme phosphodiesterase 4 (PDE4) and m3 Muscarinic Receptor Antagonists, being useful in the treatment of COPD.Se refiere a compuestos de formula I, donde: R1 es hidrogeno, halogeno, alquilo C1-C4, entre otros R2 es hidrogeno, halogeno, alquilo C1-C4, entre otros m y n son 1 a 3 R3 y R4 son independientemente H, (C3-C7) cicloalquilcarbonilo, entre otros R5 es CN, NO2, CF3 o halogeno k es 0, 1, 2 o 3 x es 0 o 1 R6 es alquilo C1-C4, alcoxi C1-C4, entre otros R7 es hidrogeno o alquilo C1-C4 opcionalmente sustituido L es una union o –CH2- L1 es una union o –(CH2)p- donde p es 1 a 4 L2 es una union -(CH2)q- donde q
