Christopher Yoon;Michael Koeris;Timothy Kuan-Ta Lu;Gregory Stephanopoulos;James J. Collins
发明人:
James J. Collins,Michael Koeris,Timothy Kuan-Ta Lu,Tanguy My Chau,Gregory Stephanopoulos,Christopher Yoon
申请号：
US13224776
公开号：
US20150050717A1
申请日:
2011.09.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
