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Electroactive Scaffold
专利权人:
发明人:
Lisa A. Scott Carnell,Emilie J. Siochi,Nancy M. Holloway,Kam W. Leong,Karina Kulangara
申请号:
US14685204
公开号:
US20150218510A1
申请日:
2015.04.13
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface electrospinning a first substantially aligned polymer fiber layer onto the first surface providing a second pre-electroded substrate surface electrospinning a second substantially aligned polymer fiber layer onto the second surface and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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