HUMANIZED ANTI TRKA ANTIBODIES WITH AMINO ACID SUBSTITUTIONS

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专利权人:

GLENMARK PHARMACEUTICALS S.A.

发明人:

BLEIN STANISLAS,OLLIER ROMAIN,SKEGRO DARKO

申请号：

IN2656MUN2014

公开号：

IN2656MUN2014A

申请日:

2014.12.30

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The present invention relates to antibodies directed against TrkA receptor and their uses including humanized anti TrkA antibodies. More specifically the present invention relates to humanized anti TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region a light chain variable region a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/