Humanized anti-TrkA antibodies with amino acid substitutions

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专利权人:

Glenmark Pharmaceuticals S.A.

发明人:

Blein, Stanislas,Ollier, Romain,Skegro, Darko

申请号：

AU2013273115

公开号：

AU2013273115A1

申请日:

2013.06.07

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.

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中国工程科技知识中心

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http://www.ckcest.cn/home/