Bandari, Suresh,Prabha Shankar, Bodapunti,Gannu, Ramesh,Rao Yamsani, Madhusudan,Van Gulik, Frederick
申请号：
AU2009224801
公开号：
AU2009224801B2
申请日:
2009.03.06
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The invention concerns a modified release doxofylline-based pharmaceutical composition, for administration once a day only. The composition contains doxofylline, in combination with a polymer chosen from a pharmaceutically acceptable cellulose derivative, a pharmaceutically acceptable methacrylate derivative, their mixtures, and pharmaceutically acceptable salts thereof； the composition may also comprise lubricating agents, such as magnesium stearate, and filling agents, such as lactose, talc, microcrystalline cellulose. The present composition provides a plasmatic concentration bioequivalent to that achieved by the immediate release composition currently available on the market, but at a lower dosage of the active ingredient.
