It refers to a controlled release formula, including: (a) one or more direct release devices, including: (I) carbon free or carbon free； (II) about 4-5% by weight of PVC matrix, such as hydroxypropylcellulose, oxidized polyoxyethylene, 3. Alginato, methylcellulose, etc.； (3) about 0.01% to 0.1% by weight of precursor such as lactose, starch or magnesium stearate； and (b) one or more slow release sub devices, including: (I) no carbohydrate or carbohydrate salt；(II) about 20-55% by weight of polycarboxylate, such as hydroxypropylmethylcellulose, polyoxyethane oxidant, alginato, etc.； and (III) about 1.0-30% by weight of soluble enhancers, such as hydroxypropylcellulose, hydroxycellulose, polyketone, polyethylene, etc； (IV) about 0.01% to 25% of precursor chemicals, such as lactose, starch or magnesium stearate. He also mentioned a process This formula provides appropriate bioavailability and long-term release and is useful in the treatment of cardiovascular diseases.SE REFIERE A UNA FORMULACION DE LIBERACION CONTROLADA QUE COMPRENDE: (A) UNA O MAS SUBUNIDADES DE LIBERACION INMEDIATA QUE COMPRENDEN: (i) UNA BASE LIBRE DE CARVEDILOL O SAL DE CARVEDILOL DE LA MISMA； (ii) APROXIMADAMENTE DE 4% A 5% EN PESO DE UN POLIMERO DE FORMACION DE MATRIZ TAL COMO HIDROXIPROPILMETILCELULOSA, OXIDO DE POLIOXIETILENO, ALGINATO, METILCELULOSA, ENTRE OTROS； (iii) APROXIMADAMENTE DE 0.01% A 0.1% EN PESO DE UN EXCIPIENTE TAL COMO LACTOSA, ALMIDON DE MAIZ O ESTEARATO DE MAGNESIO； Y (B) UNA O MAS SUBUNIDADES DE LIBERACION LENTA QUE COMPRENDEN: (i) UNA BASE LIBRE DE CARVEDILOL O SAL DE CARVEDILOL DE LA MISMA； (ii) APROXIMADAMENTE DE 20% A 55% EN PESO DE UN POLIMERO DE FORMACION DE MATRIZ TAL COMO HIDROXIPROPILMETILCELULOSA, OXIDO DE POLIOXIETILENO, ALGINATO, ENTRE OTROS； (iii) APROXIMADAMENTE DE 1.0 % A 30% EN PESO DE UN INTENSIFICADOR DE SOLUBILIDAD TAL COMO HIDROXIPROPILCELULOSA, HIDROXIETILCELULOSA, POLIVIDONA, POLIETILENGLICOL, ENTRE OTROS； (iv) APROXIMADAMENTE DE 0.01% A 25% EN PESO DE
