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DERIVIE HETEROCYCLIQUE FONDU; COMPOSITION MEDICALE CONTENANT CE DERIVE ET USAGE MEDICAL
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
FUSHIMI, NOBUHIKO,ISAJI, MASAYUKI,FUJIKURA, HIDEKI
申请号:
CA2557269
公开号:
CA2557269C
申请日:
2005.03.03
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention provides fused heterocyclicderivatives represented by the following general formula (I)or pharmaceutically acceptable salts thereof, or prodrugsthereof, which exhibit an inhibitory activity in human SGLT andare useful as agents for the prevention or treatment of a diseaseassociated with hyperglycemia such as diabetes, postprandialhyperglycemia, impaired glucose tolerance, diabeticcomplications or obesity, in the formula R1 to R4 represent H,OH, an amino group, etc.; R5 and R6 represent H, OH, a halogenatom, an optionally substituted alkyl group, etc.; Q representsalkylene, alkenylene, etc.; ring A represents an aryl group ora heteroaryl group; the following ring (R1) represents a grouprepresented by the following ring (R2); G represents a grouprepresented by the following general formula (G-1) or (G-2) (E1represents H, F or OH; and E2 represents H, F, a methyl group,etc.), and pharmaceutical compositions comprising the same, andpharmaceutical uses thereof.(see formula I)(see formula R1)(see formula II), (see formula III), (see formula R2), (see formula IV) or(see formula V)(see formula G-1)(see formula G-2)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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