NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS

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专利权人:

PIERRE FABRE MEDICAMENT

发明人:

GUMINKI YVES,BARRET JEAN-MARC,KRUCZYNSKI ANNA,IMBERT THIERRY

申请号：

TN2011000036

公开号：

TN2011000036A1

申请日:

2011.01.26

申请国别(地区):

TN

年份:

2012

代理人:

摘要：

The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C1-4alkyI, - A represents CO(CH2)n or CONH(CH2)n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.

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