The differentiation in latter stage, the cell growth that the invention provides selective induction tumor sexual cell stop and/or apoptotic method, and/or the method for inhibition of histone deacetylase (HDAC), and this method gives to comprise the pharmaceutical composition of strong hdac inhibitor.The height of the oral administration biaavailability of reactive compound is surprising in the pharmaceutical composition of the present invention.And these pharmaceutical compositions cause that unexpectedly reactive compound keeps effective blood levels in higher, the treatment for a long time.The system of taking medicine the every day that the present invention further provides these pharmaceutical composition safety, this system is to carry out easily, realizes the interior therapeutic effective dose of hdac inhibitor.
