BORD OF RIDZHENTS OF DZE YUNIVERSITI OF TEKHAS SISTEM
发明人:
DEBRABANDER Dzhef (US),ДЕБРАБАНДЕР Джеф (US),SHEJ Dzherri V. (US),ШЕЙ Джерри В. (US),VAN Ventyan (US),ВАН Вэньтянь (US)
申请号：
RU2016113279
公开号：
RU0002727516C2
申请日:
2014.09.10
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine； pharmaceuticals.SUBSTANCE: invention relates to a compound of formula I-b:(Formula I-b),where L is SO2, each R1 and R2 is independently selected from a group consisting of H and C1-4 alkyl； R3 is selected from a group consisting of C1-3 alkyl, optionally substituted with R21； ring is selected from a group consisting of, , , , , , , , , , and $； each R4, R5, R7 and R8 is independently selected from a group consisting of H, F, Cl, Br, C1-4 alkyl, N3, NH2, CF3, OCHF2, OCF3, OC1-4 alkyl, benzoyl, -OCH2C≡CH, CN, and NO2； R6 is selected from a group consisting of H, Br and R17； R9 is H； R10 is H or Br； each R11, R12 and R13 independently represents H, F, Cl or Br； each R14, R15 and R16 independently represents H, methyl or ethyl； R17 is phenyl, optionally substituted with one or more substitutes selected from the group consisting of NO2 and -NR18CO-(C1-4alkyl)； each R18 independently represents H； each R21 is independently selected from a group, consisting of H, CN and OR22； each R22 independently represents H； and to compounds of similar structure, presented by specific chemical formulas, as well as to a pharmaceutical composition for treating colon cancer, comprising a therapeutically effective amount of such compounds, and a method of treating colon cancer.EFFECT: therapeutic agents aimed at truncated proteins of adenomatous polyposis coli (APC) are proposed.9 cl, 62 dwg, 1 tbl, 3 exИзобретение относится к соединению формулы I-b:(Формула I-b) ,где L представляет собой SO2, каждый R1 и R2 независимо выбран из группы, состоящей из H и C1-4 алкила； R3 выбран из группы, состоящей из C1-3 алкила, необязательно замещенного R21； кольцо выбрано из группы, состоящей из, , , , , , , , , , и ；каждый R4, R5, R7 и R8 независимо выбран из группы, состоящей из H, F, Cl, Br, C1-4 алкила, N3, NH2, CF3, OCHF2, OCF3, OC1-4 алкила, бензоила, —OCH2C≡CH, CN, и NO2；R6 выбран из группы, состоящей из H, Br и R17； R9 представляет собой H； R10 представляет собой H или Br； ка
