Substituted tetrahydropyrans and methods of use

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专利权人:

アッヴィ・エス・ア・エール・エル;ガラパゴス・ナムローゼ・フェンノートシャップ

发明人:

キム，フィリップ・アール,ワン，シュエチン,サール，ジーニア・ビー,リウ，ボー,イエン，ミン・シー

申请号：

JP2017542799

公开号：

JP6615213B2

申请日:

2015.10.29

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

Compounds of formula (I) and pharmaceutically acceptable salts or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and m are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

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