Juan Huguet Clotet;Lluis Sola Carandell;Jordi Ceron Bertran;Jordi Bessa Bellmunt;Pere Dalmases Barjoan;Gloria Freixas Pascual;Antonio Abelino De Leon Martin
发明人:
Antonio Abelino De Leon Martin,Jordi Bessa Bellmunt,Juan Huguet Clotet,Lluis Sola Carandell,Gloria Freixas Pascual,Jordi Ceron Bertran,Pere Dalmases Barjoan
申请号：
US13643717
公开号：
US08884026B2
申请日:
2011.05.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention refers to an improved method for the preparation of compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid substantially free of its 3H-I isomer. The invention also refers to the use of said intermediate for the preparation of Rufinamide and for obtaining a new polymorphic form of Rufinamide, designed as Form R-5. The invention also refers to said new polymorph of Rufinamide, and to the composition containing it and its use as medicament. The new polymorph of Rufinamide shows good stability and appropriate physico-chemical properties for its manipulation on industrial scale. Polymorph Form R-5 will be suitable to use as pharmaceutical for the treatment of convulsions, especially for the treatment of epilepsy.
