EWERT, Stefan,BARBERIS, Alcide,URECH, David M,AUF DER MAUR, Adrian,LICHTLEN, Peter
申请号：
PH12012500758
公开号：
PH12012500758B1
申请日:
2012.04.18
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF and agr；, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF and agr；, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF and agr；-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
