STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFalpha

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专利权人:

ESBATech; an Alcon Biomedical Research Unit LLC

发明人:

Borras, Leonardo,,Gunde, Tea,,Urech, David,

申请号：

AU2013202997

公开号：

AU2013202997A1

申请日:

2013.04.08

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013202997A120130502.pdf#####ABSTRACT The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogeni city. Said antibiotics are designed for the diagnosis and/or treatment of TNFmediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.

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