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STABILIZED COMPOSITION FOR THE TREATMENT OF PSORIASIS
专利权人:
ИНК. (US);НЕКСМЕД ХОЛДИНГЗ
发明人:
ВЭЙ Уилльям Шифэн (US),ВАН Ипин (US),ПАНЬ Цзяньчжень (US),ДЗО Сунг Хи (US)
申请号:
RU2011117230/15
公开号:
RU2011117230A
申请日:
2009.10.02
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Storage-stable ointment suitable for the treatment of psoriasis, containing:! vitamin D compound; ! corticosteroid; and! N, N-di (C1-C8) alkylamino-substituted (C4-C18) alkyl (C2-C18) carboxylic acid ester, (C1-C4) alkyl (C8-C22) carboxylic acid ester; ! in petrolatum as a carrier, optionally containing mineral oil, tocopherol, or a combination of mineral oil and tocopherol. ! 2. The composition according to claim 1, characterized in that the vitamin D compound comprises calcipotriene. ! 3. The composition according to claim 1, characterized in that said corticosteroid is selected from the group consisting of a pharmaceutically acceptable salt of clobetasol and a pharmaceutically acceptable salt of betamethasone. ! 4. The composition according to claim 1, characterized in that the ester of N, N-di (C1-C8) alkylamino substituted (C4-C18) alkyl (C2-C18) carboxylic acid includes dodecyl-2- (N, N-dimethylamino) propionate (DDAIP). ! 5. The composition according to claim 1, characterized in that the vaseline carrier includes white petrolatum. ! 6. The composition according to claim 1, characterized in that the said vitamin D compound is present in the composition in a concentration range from about 0.001 to about 0.01 wt.%. ! 7. The composition according to claim 1, characterized in that said corticosteroid is present in the composition in a concentration range from about 0.01 to 0.1 wt.%. ! 8. The composition according to claim 1, characterized in that the composition comprises tocopherol in the concentration range from about 0.001 to 0.01 wt.%. ! 9. The composition according to claim 1, characterized in that the ester of N, N-di (C1-C8) alkylamino substituted (C4-C18) alkyl (C2-C18) carboxylic acid is present in the composition in a concentration range from about 0.1 to about 5 wt.%. ! 10. Composition p1. Стабильная при хранении мазь, подходящая для лечения псориаза, содержащая: ! соединение витамина D; ! кортикостероид; и ! сложный эфир N,N-ди(C1-C8)алкиламиноз
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