Yiping Wang;Jianzhen Pan;William Shifeng Wei;Sung Hi Jo
发明人:
William Shifeng Wei,Yiping Wang,Jianzhen Pan,Sung Hi Jo
申请号：
US12998261
公开号：
US09220701B2
申请日:
2009.10.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di (C1-C8)alkylamino substituted, (C4-C18)alkyl(C2-C18)carboxylic ester a (C1-C4)-alkyl(C8-C22)carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1-C8) alkylamino substituted, (C4-C18)alkyl(C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).
