Alberto Cerri,Marco Torri,Silvia Armaroli,Leonardo Banfi,Giuseppe Bianchi,Giulio Carzana,Patrizia Ferrari,Rosamaria Michaeletti,Simona Sputore,Maria Pia Zappavigna
申请号：
US12295497
公开号：
US08609644B2
申请日:
2007.04.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
