CERRI, ALBERTO,TORRI, MARCO,ARMAROLI, SILVIA,BANFI, LEONARDO,BIANCHI, GIUSEPPE,CARZANA, GIULIO,FERRARI, PATRIZIA,MICHELETTI, ROSAMARIA,SPUTORE, SIMONA,ZAPPAVIGNA, MARIA PIA
申请号：
CA2649175
公开号：
CA2649175C
申请日:
2007.04.11
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of formula (I)(see formula I)wherein: the groups are as defined in the description, are useful for thepreparation of medicaments for the treatment of cardiovasculardisorders, in particular heart failure and hypertension. The compoundsare inhibitors of the enzymatic activity of the Na+,K+-ATPase. Saidcompounds are used for the preparation of a medicament for thetreatment of a disease caused by the hypertensive effects of endogenousouabain, such as renal failure progression in autosomal dominantpolycystic renal disease (ADPKD), preeclamptic hypertension andproteinuria and renal failure progression in patients with adducinpolymorphisms.
