A networked clinical diagnostic analyzer is disclosed with support for monitoring by a remote back office. The disclosed analyzer includes a module to detect in real-time events of interest while allowing the back office to modify the definitions of the events. The module may be networked using virtual private networking into the back office network, which is usually different from the network at the site of the clinical diagnostic analyzer's deployment. The real-time alerts allow both a quick response to actual or expected error conditions and the downloading of logged data that is likely of most interest and relevance.