Methods and systems are presented for analyzing physiological data at an operating system of a user device in order to identify emergencies or medically significant events in real-time. In some embodiments, physiological data from a wearable physiological monitoring device may be analyzed in real-time on a user device (e.g., smartphone). In some embodiments, local and remote analyses of motion activity data feeds from data sources may be used to identify medically significant events in real-time.