John E. THOMPSON,Zhong Sun,Catherine Taylor,Richard Dondero,Zhenyu Cheng
申请号：
US13895756
公开号：
US20140171374A1
申请日:
2013.05.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.
