TOMALIA, DONALD A.,托玛利亚 多讷德Ａ,托瑪利亞 多訥德Ａ,SWANSON, DOUGLAS R.,史温森 道格拉斯Ｒ,史溫森 道格拉斯Ｒ,HUANG, BAOHUA,黄伯华,黃伯華,PULGAM, VEERA REDDY,普葛姆 维拉瑞迪,普葛姆 維拉瑞迪,HEINZELMANN, JOSEPH R.,汉恩扎尔曼 约瑟芬Ｒ,漢恩扎爾曼 約瑟芬Ｒ,SVENSON, SONKE,史,托玛利亚 多讷德A,托瑪利亞 多訥德A,史温森 道格拉斯R,史溫森 道格拉斯R,普葛姆 维拉瑞迪,普葛姆 維拉瑞迪,汉恩扎尔曼 约瑟芬R,漢恩扎爾曼 約瑟芬R
申请号：
TW095138387
公开号：
TWI384032B
申请日:
2006.10.18
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael’s reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.本發明係揭示具有增強的放大率及內部官能度的樹枝狀聚合物。這些樹枝狀聚合物之製法為使用快速、反應性開環化學作用(或其它快速反應)及以控制方式使用分支小室(branch cell)試劑以快速並精確地建構具有更完全的化學性質之精確結構之世代型樹枝狀高分子結構，其通常為單一產物、含較低過量之試劑、僅需要較低稀釋程度、適於較高生產力方法、更容易調整至商業大小、使用新物質範圍，及較低成本。所製成之樹枝狀組成物具有新穎內部官能度、更高安定性(例如熱安定性，及幾乎不發生逆麥可反應(Michaels reaction))，且可以於較低世代下達到封包表面密度。非可預期地，多官能性分支小室試劑與多官能性核心所進行之這些反應並不能產生交聯物質。此等樹枝狀聚合物可作為供油/水乳液使用之去乳化劑、用於紙製造之濕強度劑、質子清除劑、聚合物、奈米尺度單體、電子顯微術之校準標準物、製造尺寸選擇膜，及用以修飾水性配方(諸如油漆)之黏度的藥劑。當這些樹枝狀聚合物之載送物質係與其表面及/或內部締合時，則由於該樹枝狀聚合物之獨特性質，所以這些樹枝狀聚合物具
