The present disclosure is in the field of medical devices and gene editing, particularly the use of medical devices for the targeted delivery of gene editing reagents in vivo or ex vivo. The methods and materials described herein provide control over the location and timing of delivery, along with the ability to deliver gene editing reagents as nucleic acids, virus particles, or protein. Furthermore, the methods and materials can be used to reduce or eliminate the systemic spread of gene editing reagents in non-target tissues/organs. The methods and devices described herein can be used for gene editing in animals.
