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B-amiloide modulator; preparation procedure; pharmaceutical ingredients; compounds (3.2.1) [3.2.1] oct-8-il) for the treatment of diseases such as Alzheimer's disease and Down's disease;
专利权人:
F. HOFFMANN-LA ROCHE
发明人:
GREEN, LUKE,LUEBBERS, THOMAS,BAUMANN, KARLHEINZ,THOMAS, ANDREW,LIMBERG, ANJA,GREEN LUKE,BAUMANN KARLHEINZ,LUEBBERS THOMAS,THOMAS ANDREW,LIMBERG ANJA
申请号:
CL2013002474
公开号:
CL2013002474A1
申请日:
2013.08.28
申请国别(地区):
CL
年份:
2014
代理人:
摘要:
The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &bgr;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.COMPUESTOS DERIVADOS DE PIPERIDINA PUENTEADA (3-AZA-BICICLO[3.2.1]OCT-8-IL), MODULADORES DE B-AMILOIDE; PROCEDIMIENTO DE PREPARACIÓN; COMPOSICIÓN FARMACÉUTICA; Y USO EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO ALZHEIMER, SÍNDROME DE DOWN, ENTRE OTRAS.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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