B-amiloide modulator; preparation procedure; pharmaceutical ingredients; compounds (3.2.1) [3.2.1] oct-8-il) for the treatment of diseases such as Alzheimer's disease and Down's disease;
The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of &bgr;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.COMPUESTOS DERIVADOS DE PIPERIDINA PUENTEADA (3-AZA-BICICLO[3.2.1]OCT-8-IL), MODULADORES DE B-AMILOIDE; PROCEDIMIENTO DE PREPARACIÓN; COMPOSICIÓN FARMACÉUTICA; Y USO EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO ALZHEIMER, SÍNDROME DE DOWN, ENTRE OTRAS.