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БИЦИКЛИЧЕСКИЕ НИТРОИМИДАЗОЛЫ, КОВАЛЕНТНО СОЕДИНЕННЫЕ С ЗАМЕЩЕННЫМИ ФЕНИЛОКСАЗОЛИДИНОНАМИ
专利权人:
GLOUBAL EHLAENS FOR TB DRAG DIVELOPMENT
发明人:
DING CHARLZ Z.,ДИНГ Чарльз З.,LU GEHNLJAN,ЛУ Гэньлян,KOMBRINK KIT,КОМБРИНК Кит,CHEHN DJANTSZJUN,ЧЭНЬ Дяньцзюнь,SONG MINZOO,СОНГ Минзоо,VAN TSZJANCHEHN,ВАН Цзяньчэн,MA ZHENKUN,МА Женкун,PALMER BRAJAN D
申请号:
RU2010143541/04
公开号:
RU0002504547C2
申请日:
2009.03.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: biotechnologies.SUBSTANCE: invention refers to a number of bicyclic nitroimidazole-replaced phenyloxazolydinones of the following structural formula (I):,containing nitroimidazole circle, or to its pharmaceutically acceptable salt where R1 represents hydrogen, (C1-C6)alkyl or aryl n is equal to 0, 1 or 2 X1 and X2 independently represent H, CF3, CI, OCF3 or F G represents -OH, triazole or -NHCOR2 R2 represents (C1-C6)alkyl, cycloalkyl or aryl and L represents a bond or a linker group chosen from any combination 2-3 of the following groups: 1) (C1-C6)alkylene, 2) (C3-C8)cycloalkylene, 3) arylene, arylene-replaced CN, ore arylene-replaced F, 4) group chosen from the group consisting of,where R10 represents H, CF3, hydroxyl, amino, alkyl, alkylamino, alkoxy or aryl, and R13 represents H, hydroxyl, amino, alkyl, alkyl amino, alkoxy or aryl, or R13 in combination with nitroimidazole circle can form spiral-shaped structure, 5) -C(=O)-, 6) -O-, 7) -S(O)n-, in which n is equal to 0.1 or 2, 8) -N(R3)-, 9) -C(R4)=C(R5)-, R3 represents hydrogen, (C1-C6) alkyl or aryl, and R4 and R5 represent hydrogen, (C1-C6) alkyl or aryl, or R4 and R5 can be combined together so that they can form a bond. Besides, the invention refers to pharmaceutical composition for treatment of bacterial infection based on compounds of formula I, as well as to a bacterial infection treatment method.EFFECT: invention describes new compounds that have antibacterial activity against a line of wild type and stable lines of pathogenic microorganisms, and as a result, are suitable for prevention, control and treatment of a number of human and mammal bacterial infections caused by these pathogenic microorganisms such as bacillus Kochii.15 cl, 93 ex, 1 tbl, 22 dwgИзобретение относится к ряду бициклических нитроимидазол-замещенных фенилоксазолидинонов структурной формулы (I):содержащее нитроимидазольное кольцо, или к его фармацевтически приемлемой соли где R1 представляет собой водород, (С1-С6)алкил или ари
来源网站:
中国工程科技知识中心
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